Tg(Afp-GFP) expression marks primitive and definitive endoderm lineages during mouse development
نویسندگان
چکیده
منابع مشابه
Osterix marks distinct waves of primitive and definitive stromal progenitors during bone marrow development.
Mesenchymal stem and progenitor cells (MSPCs) contribute to bone marrow (BM) homeostasis by generating multiple types of stromal cells. MSPCs can be labeled in the adult BM by Nestin-GFP, whereas committed osteoblast progenitors are marked by Osterix expression. However, the developmental origin and hierarchical relationship of stromal cells remain largely unknown. Here, by using a lineage-trac...
متن کاملChanges in S1P1 and S1P2 expression during embryonal development and primitive endoderm differentiation of F9 cells.
Sphingosine 1-phosphate (S1P) is a ligand for S1P family receptors (S1P(1)-S1P(5)). Of these receptors, S1P(1), S1P(2), and S1P(3) are ubiquitously expressed in adult mice, while S1P(4) and S1P(5) are tissue specific. However, little is known of their expression during embryonal development. We performed Northern blot analyses in mouse embryonal tissue and found that such expression is developm...
متن کاملLIF supports primitive endoderm expansion during pre-implantation development.
Embryonic stem cells (ESCs) are pluripotent cell lines that can be maintained indefinitely in an early developmental state. ESC culture conditions almost always require the cytokine LIF to maintain self-renewal. As ESCs are not homogeneous but contain multiple populations reminiscent of the blastocyst, identifying the target cells of LIF is necessary to understand the propagation of pluripotenc...
متن کاملBmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development.
The transcription factors Nanog and Gata6 are critical to specify the epiblast versus primitive endoderm (PrE) lineages. However, little is known about the mechanisms that regulate the protein stability and activity of these factors in the developing embryo. Here we uncover an early developmental function for the Polycomb group member Bmi1 in supporting PrE lineage formation through Gata6 prote...
متن کاملEvalauation of Laminin Expression during Mouse Lens Development
Introduction: Among the components of the extracellular matrix (ECM) and basement membrane (BM), laminitis heterotrimeric glycoprotein (laminin) and collagen type IV are the most important. In a previous study we have examined the role of collagen type IV in the developing lens capsule. The present study aims to determine the appearance and distribution of laminin in the BM and ECM of lenses ...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 2006
ISSN: 1058-8388,1097-0177
DOI: 10.1002/dvdy.20843